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So what have you been doing with your summer? I personally have been fucking around all over the world like Paris Hilton with a beer gut instead of that hairless dog and a shaved hoo-hah. By world, I just mean the selected states in the U.S., but that cheap oem software buy software

Tags: software, world, hah, hoo, shaved

Part 4 of a 4-part series of short posts intended to clear out my bloggestive tract. Hold your nose! Well, I held out for a week. Then I read the comments. Argh! Actually they were fine. Nice comments, all around. Whew. I don't have any big themes to talk about today, but I've got a couple of little ones, let's call 'em bloguettes, that I'll lump together into a medley for today's entree. Bloguette #1: Ruby Sneaks ended accessible Python I was in Barnes today, doing my usual weekend stroll through the tech section. Helps me keep up on the latest trends. And wouldn't you know it, I skipped a few weeks there, and suddenly Ruby and Rails have almost as many books out as Python. I counted eleven Ruby/RoR titles tonight, and thirteen for Python (including one Zope book). And Ruby had a big display section at the end of one of the shelves. Not all the publishers were O'Reilly and Pragmatic Press. I'm pretty sure there were two or three others there, so it's not just a plot by Tim O'Reilly to sell more books. Well, actually that's exactly what it is, but it's based on actual market research that led him to the conclusion that Rails and Ruby are both gathering steam like nobody's business. I like a lot of languages. Really, I do. But I use Ruby. I'm not even sure if I like Ruby. The issue might just be irrelevant to whether I use it. I like OCaml, for instance, but I don't use it. I don't like Java, but I do use it. Liking and using are mostly orthogonal dimensions, and if you like the language you're using even a little bit, you're lucky. That, or you just haven't gotten broad enough exposure to know how miserable you ought to be. I use Ruby because it's been the path of least resistance for most of my programming tasks since about 3 days after I started messing with it, maybe 4 years ago. I don't even really know Ruby all that well. I never bothered to learn it. I did read "Ruby in a Nutshell" cover-to-cover, but it's a short read (and it's a bit out of date now.) Then I read bits of "Programming Ruby", but not all of it. And now I use Ruby for everything I can, any time I have any choice in the matter. I don't even mind that I don't know the language all that well. It has a tiny core that serves me admirably well, and it's easy to look things up when you need to. I do a lot more programming in Python than in Ruby -- Jython in my game server, and Python at work, since that's what everyone there uses for scripting. I have maybe 3x more experience with Python than with Ruby (and 10x more experience with Perl). But Perl and Python both have more unnecessary conceptual overhead, so I find I have to consult the docs more often with both of them. And when all's said and done, Ruby code generally winds up being the most direct and succinct, whether it's mine or someone else's. I have a lot of trouble writing about Ruby, because I find there's nothing to say. It's why I almost never post to the O'Reilly Ruby blog. Ruby seems so self-explanatory to me. It makes it almost boring; you try to focus on Ruby and you wind up talking about some problem domain instead of the language. I think that's the goal of all programming languages, but so far Ruby's one of the few to succeed at it so well. If only it performed better. *Sigh*. Well, its performance is in the same class as Perl/Python/JavaScript/Lua/Bash/etc., so there are still plenty of tasks Ruby's admirably suited for. I think next year Ruby's going to be muscling in on Perl in terms of mindshare, or shelf-share, at B&N. Bloguette #2: Java's Biggest Dog (Indeed) I still do most of my programming in Java -- at least half of it, maybe more. The Java platform continues to make amazing strides. The newest incarnation (JDK 6) has lots of goodies I can't wait to play with. Like Rhino, for instance, and although they appear to have gutted it, it's still awesome. I think it's the best choice they possibly could have made. Thank God they didn't bundle Groovy. What a catastrophe that was, and still is, and would have been for Java if they'd bundled it. Rhino rocks. The JVM is just getting faster and more stable, and there are even some OK libraries that come with it. I used to think the Java platform libraries were the cat's meow. Heck, I thought they were the whole damn cat. But working with better libraries in miscellaneous other languages has got me thinking that Java's libraries are hit-or-miss. Example: Java's concurrency libraries (java.util.concurrent[.*]) are to die for. I mean, if you're stuck with threads. I think in the fullness of time, hand-managed threads will be history, but in the meantime, Java's concurrency libraries are just superb. I recently ported a medium-sized Python program I'd written (about 1200 lines of fairly dense Python code) to Java, because the Python was taking about an hour to run, and I wanted to parallelize the work. I spent about 3 days doing the rewrite: one day on the straight port, a day adding in the threading, and a day fine-tuning it. The straight port wound up as 1300 lines of Java (surprising that it wasn't bigger, but maybe I code in Python with a Java accent?), and ran about 50% faster, down to about 30 minutes. After adding in the threading and state machine, the program ran in 50 to 60 seconds. So I got an order of magnitude improvement with only about a 50% increase overall in program size. The vast majority of the improvement was attributable to the threading, which in turn would have taken me FAR longer if I'd been using raw synchronization primitives. The java.util.concurrent stuff made it a snap. On the other hand, Java's DOM implementation completely blows chunks. It quickly became the bottleneck in my application, due to an O(n) algorithm I stumbled across with no good workaround for. I can't remember exactly where it was (this was back in July), but I found a sheepishly apologetic comment from the author in the online docs. It was something to do with setting attributes on nodes while you're doing a traversal of some sort: something you'd definitely want to be fast, but it had at least linear performance, maybe worse, and now accounts for 95+% of my app's processing time. And of course Java's DOM interface blows too, because you can't create subclasses or decorators or do anything useful with the DOM other than use it as a temp container until you've transfered the data to something more flexible. Java's collections library is decent, but not superb. It's nice having the data structures they provide, but they're not very configurable, and the language itself makes them often cumbersome. For instance, you can have a WeakHashMap (nice), or an IdentityHashMap (nice), or a ConcurrentHashMap (also nice), but you can't combine any two of those three properties into a single hashtable. Lame. And java.util is missing implementations and/or interfaces for a bunch of important data types like priority queues (you're stuck using a TreeSet, which is overkill), the disjoint set ADT, splay trees, bloom filters, multi-maps, and of course any kind of built-in graph support. Java hyper-enthusiasts will tell you: "well, go write your own! Or use one of the many hopefully robust implementations on the web!" That seems lame to me. We're talking about data structures here: they're more fundamental than, say, LDAP libraries and much of the other stuff Sun's bundling these days. It's smartest to provide robust, tuned implementations of these things, because it empowers average Java programmers to write faster, more reliable code. Oh, and let's not even get me started with java.nio. What a mess! It's pretty gross, especially if you come from the comparatively simple background of select() and poll() on Unix. But maybe the grossness was necessary. I'll give them the benefit of the doubt. What bugs me isn't that the API is conceptually weird and complex (and buggy as hell last time I checked); what bugs me is that nobody at Sun bothered to put a layer atop java.nio for ordinary programmers. Like, say, a nonblocking DataInputStream that takes a type to read, a Buffer, and a callback to call when it's finished reading. So every frigging Java programmer on the planet has to write that exact class -- or just flail around with the raw APIs, which is what I think most of them do. And look what they did to poor LDAP! I mean, the LDAP bindings are dirt-simple in every language I've ever used. It's supposed to be lightweight -- that's what the "L" stands for, fer cryin' out loud. JNDI is this huge monster. So is JMX. I mean, Java libraries have this way of being so bloated and overengineered. But whatever; I've digressed. Java's libraries are not its biggest failing. The libraries (as I said) are decent, and the platform (in terms of tools, speed, reliability, documentation, portability, monitoring, etc.) really raises the bar on all those other loser languages out there. All of 'em. It's why no better languages have managed to supplant Java yet. Even if the language and its libraries are (on the whole) better than Java's, they also have to contend with the Java platform, and so far nobody's been able to touch it, unless maybe it's .NET, but who cares about .NET? Certainly not Amazon.com or Yahoo! or Google or any other important companies that I'm aware of. Literals Anyway, Java's biggest failing, I've decided, is its lack of syntax for literal data objects. It's an umbrella failing that accounts for most of the issues I have with the language. The idea behind literals is that you have some sort of serialized notation for your data type, and it's part of the language syntax, so you can embed pre-initialized objects in your code. The most obvious ones are numbers, booleans and strings. It's hard to imagine life without support for numeric literals, isn't it? Well, Java's support is limited at best. There's no syntax for entering a binary value, for instance, like "0b10010100". And there's no BigInteger/BigDecimal syntax, so working with them is a disaster and nobody does it if they can help it. Heck, Java doesn't even have unsigned ints and longs. But Java does more or less the bare minimum for numbers, so people don't notice it much. Imagine if there were no String literals, so that instead of this: String s = "Hello, world!"; you had to do this: StringBuffer sb = new StringBuffer(); sb.append('H'); sb.append('e'); sb.append('l'); sb.append('l'); sb.append('o'); sb.append(','); sb.append(' '); sb.append('W').append('o').append('r').append('l').append('d').append('!'); String s = sb.toString(); Not only is the latter bloated and ugly and error-prone (can you spot the error in mine?), it's also butt-slow. Literals provide the compiler with opportunities for optimization. Well, unfortunately this OOP garbage is exactly what you have to do when you're initializing a hashtable in Java. Nearly all other languages these days have support for hashtable/hashmap literals, something like: my_hashmap = { "key1" : "value1", "key2" : "value2", "key3" : "value3", ... } That's the syntax used by Python and JavaScript, but other languages are similar. The Java equivalent is this: Map<String, String> my_hashmap = new HashMap<String, String>(); my_hashmap.put("key1", "value1"); my_hashmap.put("key2", "value2"); my_hashmap.put("key3", "value3"); ... It might not look that much worse from this simple example, but there are definitely problems. One is optimization; the compiler is unlikely to be able to optimize all these method calls, whereas with a literal syntax, it could potentially save on method call overhead during construction of the table (and maybe other savings as well.) Another is nested data structures. In JavaScript (and Python, Ruby, etc.) you just declare them in a nested fashion, like so: my_thingy = { "key1": { "foo": "bar", "foo2": "bar2"}, "key2": ["this", "is", "a", "literal", "array"], "key3": 37.5, "key4": "Hello, world!", ... } It would be hard to do this particular one in Java 5 because of the mixed value types, though it's probably not an issue since using mixed-type data structures is something you rarely do in practice, even in dynamically-typed languages. But even if all the values were hashes of string-to-string, how are you going to do it in Java without literals? You can't. You're stuck with: Map<String, Map<String, String>> my_hashmap = new HashMap<String, HashMap<String, String>>(); Map<String, String> value = new HashMap<String, String>(); value.put("foo", "bar"); value.put("foo2", "bar2"); my_hashmap.put("key1, value); value.clear(); value.put("foo3", "bar3"); value.put("foo4", "bar4"); my_hashmap.put("key2, value); ... And then you find out later that your clever clear() optimization (instead of creating a new HashMap object for each value) busted it completely. Whee. Java programmers wind up dealing with this kind of thing by writing generic helper functions, and it winds up layering even more OOP overhead onto something that ought to be a simple declaration. It also tends to be brutally slow; e.g. you could write a function called buildHashMap that took an array of {key, value, key, value, ...}, but it adds a huge constant-factor overhead. This is why Java programmers rely on XML so heavily, and it imposes both an impedance mismatch (XML is not Java, so you have to translate back and forth) and a performance penalty. But the story doesn't end there. What about Vector/ArrayList literals? Java has primitive array literals, which is nice as far as it goes: String[] s = new String[]{"fee", "fi", "fo", "fum"}; Unfortunately, Java's primitive arrays are a huge wart; they don't have methods, can't be subclassed, and basically fall entirely outside the supposedly beautiful OOP-land that Java has created. It was for performance, to help capture skeptical C++ programmers, and they have their place. But I don't see why they should have all the syntactic support. I mean, the [] array-indexing operator is ONLY available for Java arrays. Sure would be nice to have it for ArrayLists, wouldn't it? And Strings? And FileInputStreams? But for some reason, Java gave arrays not one, but TWO syntactic sugarings, and then didn't give that sugar to anything else array-like in the language. So for building ArrayLists, LinkedLists, TreeMaps and the like, you're stuck with Swing-style code assemblages. I think of them as Swing-style because I used to do a lot of AWT and Swing programming, back when I was a Thick Client kind of guy, and they have a distinct(ly unpleasant) footprint. It looks vaguely like this, in pseudo-Swing: Panel p = new Panel(new FlowLayout()); JButton b = new JButton("Press me!"); b.setEventListener(somethingOrOther); p.add(b); JSomething foo = new JSomething(blah, blah); foo.setAttribute(); foo.setOtherAttribute(); foo.soGladIDontDoThisKindOfThingAnymore(); p.add(foo); ... Building UIs in Swing is this huge, festering gob of object instantiations and method calls. It's OOP at its absolute worst. So people have come up with minilanguages (like the TableLayout), and declarative XML replacements like Apache Jelly, and other ways to try to ease the pain. I was on a team at Amazon many years ago that was planning to port a big internal Swing application to the web, and we were looking at the various ways to do web programming, which at the time (for Java) were pretty much limited to JSP, WebMacro, and rolling your own Swing-like HTML component library. We experimented with the OOP approach to HTML generation and quickly discarded it as unmaintainable. (Tell that to any OOP fanatic and watch their face contort as they try to reconcile their conflicting ideas about what constitutes good programming practice.) The right solution in this case is, of course, a Lisp dialect; Lisp really shines at this sort of thing. But Lisp isn't so hot at algebraic expressions, and the best Lisp machines no longer look so cutting-edge compared to the JVM, and blah blah blah, so people don't use Lisp. So it goes. The next-best solutions are all about equally bad. You have your XML-language approaches (like Jelly, but for the web), but they don't give you sufficient expressiveness for control flow -- presentation logic really does require code, and it gets ugly in XML in a real hurry. You have your JSP-style templating approaches, and they aren't bad, but they can have as many as 4 or 5 different languages mixed in the same source file, which presents various problems for your tools (both the IDEs and the batch tools). And then you have a long tail of other approaches, none of which manage to be very satisfying, but that's not really the fault of the languages. It's the browsers' fault: they START with three languages (HTML, CSS, and JavaScript), rather than having just one language to control the entire presentation, and it only goes downhill from there. But NONE of the approaches to web templating is as bad as Swing-style programming, with a huge thicket of calls to new(), addChild(), setAttribute(), addListener(), and the like. The only approach that's worse (and even it might just be tied) is raw HTML printing: print("<html><body>...</body></html>"); So we're all in agreement. OOP-style assembly of parents and children is the worst way to generate HTML. You want to use declarations; you want a template , something that visually looks like the end result you're trying to create. Well, it's the exact same situation for data structures, isn't it? You'd rather draw a picture of it (in a sense, that's exactly what you're doing with syntax for literals) than write a bunch of code to assemble it. This is all assuming that you're working with a small data set, of course. But that happens all the time in real-world programs; it's ubiquitous. So you kinda want your language to support it syntactically. And so far we've only covered literal syntax for HashMaps and ArrayLists (which you can combine to produce various kinds of custom Trees.) Already Java's way behind other languages, and we haven't discussed any richer data types. Like, say, objects. JavaScript does it the best here, IMO, in the parity between hashes and objects. It's not really possible in Ruby or Python to declare a class, then create instances of the class using literal notation the way you can in JavaScript, where the keys are the names of instance variables. Fortunately you can accomplish this in either Ruby or Python with just a smidge of metaprogramming, so it's spilt milk at worst. In Java, you only have one big hammer (instantiation), and one big wrench (the method call), so that's what you use. All you can really do to help is create a constructor that takes arguments that populate the instance variables. But if any of your instance variables are collections (other than arrays), then you're back to the old create-setprops-addchild, create-setprops-addchild pattern again. And what about functions? Ruby and JavaScript and Lisp and Scheme and Lua and Haskell and OCaml and most other self-respecting languages have function literals. That is, they have a syntax for declaring an instance of a function as a data object in your code that you can assign to a variable, or pass as a parameter. (Python has them too, but unfortunately they can only be one line, so Python folks prefer to pretend anonymous functions aren't very important. This is one of the 10 or so big problems caused by Python's whitespace policy. Don't ever let 'em tell you it doesn't cause problems. It does. Maybe it's worth the trade-off; that's a personal style preference, but they should at least admit the tradeoff exists.) Well, Java sort of has them, but Java's static type system doesn't have a literal syntax for a method signature. It's pretty easy to imagine one, e.g. something like: (int, int) -> String x; This imaginary syntax declares a variable x that takes 2 ints as parameters and returns a string. Lots of languages have signature-syntax of some sort, and Java's syntax space is definitely sparse enough that they could pick a good syntax for it without fear of collisions, even conceptual collisions. But no such luck. Instead, when you want to do this sort of thing you have to declare a named interface, and then inside of it declare at least one named method (which is where the params and return type show up), and then you're still not done, because when you create the function you have to create an anonymous (or named) class that contains the definition of the function that matches the interface. Yuck. But at least they let you do it; the alternative of not having it at all is definitely worse. Still... isn't syntactic sugar nice? I mean, they added the "smart" for-loop, which Java programmers just rave about. So someone, somewhere in the Java community thinks syntax is good. I'm not sure many of them really understand the difference between syntactic sugar (into which category the "smart" for-loop falls) and orthogonal syntax, in which the basic operators apply to all data types for which those operators make sense, and there are literal declarations possible for every data type. Let alone the next step, which is extensible syntax -- but that idea strikes fear into the hearts of many otherwise brave Java programmers, and Rubyists and Pythonistas as well, so let's back it up a notch to "orthogonal", and keep everyone calm. So there you have it: Java's biggest failing. It's the literals. No literal syntax for array-lists (or linked lists or tree sets), nothing for hashtables, nothing for objects of classes you've personally defined, none for functions or function signatures. Java programmers all around the world spend a *lot* of their time working around the problem, using XML and YAML and JSON and other non-Java data-declaration languages, and writing tons of code (whole frameworks, even) for serializing and deserializing these declarations to and from Java. For the smaller stuff, they just write helper functions, which wind up being bloated, inefficient, error-prone, and extremely unsatisfying. Java's next-biggest failing may well be the lack of orthogonality in its set of operators. We can live without operator overloading, I suppose (the simplest form of extensible syntax), but only if Sun makes operators like [] and + actually work for objects other than arrays and Strings, respectively. Jeez. Epiblogue You can draw your own conclusions about why suddenly there are all these books on Ruby appearing on the bookshelves. It's a mix of truths, no doubt. And you can draw your own conclusions about why Sun's adding support for scripting languages to the JVM, rather than simply fixing Java so that people don't want (need, really) to use those other languages. But when you dig down into a programming language, and you get past all the hype and the hooplah, what you find is a set of policies and decisions that affect your everyday life as a programmer in ways you can't ignore, and that no amount of hype will smooth over. If your language is sitting on you like an invisible elephant, and everyone using the language is struggling to work around the same problems, then it's inevitable that other languages will come into play. Libraries can make you more productive, but they have almost no effect on the scalability of the language. Every language has a complexity ceiling, and it's determined by a whole slew of policy and design decisions within the language, not the libraries. The slew includes the type system (with its attendant hundreds of mini-policies), and the syntax, and it also includes the language's consistency: the ratio of rules to exceptions. Java's demonstrating quite clearly that at a certain level of complexity, the libraries and frameworks start to collapse under their own weight. People are always writing "lightweight" replacements for existing fat Java libraries and frameworks, and then the replacements get replaced, ad infinitum. But have you ever seen anyone write a replacement for XPath? Nope. It's not like everyone is rushing out to write the next big XML-querying framework. This is because XPath is a language , not a library, and it's orders of magnitude more conceptually scalable than the equivalent DOM manipulations. Object-Oriented Programming. Touted even by skeptics as a radical leap forward in productivity, and all OOP really is boils down to a set of organizational techniques. Organization is nice, sure. But it's pretty clear that OOP alone doesn't cut it; it has to be supplemented with Language-Oriented Programming and DSLs. And all languages, DSLs and general-purpose languages alike, have to be designed to maximize consistency; each inconsistency and special-case in the language adds to its conceptual overhead and lowers the complexity ceiling. So you can look at the shelves filling up with Ruby books and chalk it up to marketing hype, but I have a different theory. I think it's entirely due to complexity management: Ruby does a better job of helping managing complexity than its competitors. It doesn't do a perfect job, mind you -- far from it. But it's enough of a step forward in productivity (even over Perl and Python) that it's managing to shoulder its way in to a pretty crowded language space. With that in mind, despite my griping about Java's failings, I think Sun might actually be doing the right thing by introducing scripting languages (and improving support for them in the JVM.) Maybe. Their investment isn't really so much in Java as it is in the JVM; the JVM is their .NET. Java's not really about productivity, not really -- it's got a lot of strengths (performance, deployment, reliability, static checkability, and so on), but productivity isn't high on the list. So maybe the best way to address the productivity issue, for folks who really need it more than raw performance, is to introduce new JVM languages rather than try to pull Java in two directions. We'll see. And with that, I think I've officially un-blocked myself; I seem to be able to blog again. So I'm declaring the Blogger's Block series finished! BloggersBlock block = new BloggersBlock(); block.setFinished(true); block.tieOffAndStuff(); blog.addChild(block); ... cheap oem software buy software

Tags: java, language, ruby, string, literal

That’ll Be The Day “All I know is just what I read in the papers.” Will Rodgers,1879-1935 I await the day when The New York Times runs a series of “good news” articles about the state of American health care. The series might have these titles, • Americans Trust Their Doctors • Americans Have Greater and Quicker Access to High Tech Diagnostic and Curative Care Than Any Other Nation • Foreign Physicians Flock to America for Training Unavailable in Their Country • Record Numbers of Canadians Cross Border for Life-Saving Care • America Achieves Unprecedented Longevity Gains in Last Decade • Americans Receive 80 Percent of Noble Prizes in Medicine • Research at American Pharmaceutical Companies Produces 90 Percent of the World’s New Drugs • America’s Innovative Health System’s Variety and Choice the Wonder of The World That’ll be the day. The Times in 2005 and 2006 had a series of a dozen articles entitled “Being A Patient.” These focused largely on the perils of being a patient in America. Now The Times is embarked on a series on medicine and money, focusing on profit-mongering drug and medical device companies in league with greedy specialists to bilk the public. It all comes down to altitude and attitude. From their lofty perch, Th e New York Time’s editorial staff has yet to tumble to the reality America is basically a conservative nation, distrusts centralized government, wants choices of care and providers, demands access to the wonders of high tech medicine, and believes a market-based system, with all its faults, such as profits for entrepreneurial and innovative health care companies and , are worth the price and value received. It is almost as though The Times denies the existence of entrepreneurial capitalism in American health care. Our health system blends innovative large and small firms striving for economic growth. Such a system entails risk – workers who lose jobs and health insurance, widening of gaps between winners and losers, competition with some jobs going to skilled workers abroad who have increasing skills, occasional bankruptcies among those unable to pay health care bills. American capitalism is imperfect. It requires oversight to reduce risks without losing entrepreneurial vigor. Unremitting accusations of bad faith and constant “bad news” stories don’t strengthen health care. Read the The New York Times, and you’ll come away believing pervasive avaricious greed corrupts American health care and will break our already “broken” system. From May 9 through May 11, The Times ran 10 articles on how drug companies deceived the public and entered into unholy alliances with doctors to sell more drugs to produce more revenue for doctors, how doctors willingly entered into these alliances solely for material gain, and how lobbyist-tainted and incompetent FDA failed to monitor new drugs and harmed patient safety. The May 9 front page, right top column, the prime spot for highlighting news, featured these headlines, Doctors Reaping Millions for Use of Anemia Drugs. Payments from Industry. Concerns over Safety – Critics See Incentives for Higher Doses. The opening Section read: “T wo of the world’s largest drug companies are paying hundreds of millions of dollars to doctors every year in return for giving their patients anemia medicines, which regulators now say may be unsafe at commonly used doses. The payments are legal, but very few people outside of the doctors who receive them are aware of their size. Critics, including prominent cancer and kidney doctors, say the payments give physicians an incentive to prescribe the medicines at levels that might increase patients’ risks of heart attacks or strokes. Industry analysts estimate that such payments — to cancer doctors and the other big users of the drugs, kidney dialysis centers — total hundreds of millions of dollars a year and are an important source of profit for doctors and the centers. The payments have risen over the last several years, as the makers of the drugs, Amgen and Johnson & Johnson, compete for market share and try to expand the overall business.” The Times appears bent on publishing on its front pages “All the Bad News that’s Fit to Print about U.S. Health Care.” The May 9 article is part of a series of medicine and money, all decrying collusive relationships between big business and bad doctors. The Times series focus on the pharmaceutical industry and medical device industries , and how these industries reward specialists who overuse products for financial gain. To The Times, the American health system has become a morality play, • the good guys (The Times and other assorted elites and policy pundits) vs. the bad guys (profiteering health companies and doctors); • the greedy (well-healed executives and “rich” doctors) vs. the needy (poor patients in the throes of cancer or kidney dialysis); • the high brows (academics and journalists who know what’s right for the common good) vs. the low brow commercial types (who do almost everything wrong as long as it suits their own financial self-interest). I don’t wish to pick a fight with a media outlet who buys ink by the barrel. I know “bad news” sells better than “good news.” I know The Times considers itself the Watchdog and Whistle-Blower against mean-spirited, profiteering conservatives. I don’t question our capitalistic system needs oversight to reduce abuses. I’m simply seeking more balance in The Times reporting. For an example of this imbalance, in its May 9 piece, The Times dismisses America doctors’ overuse of anemia-correcting drugs for cancer and dialysis as a deliberate effort to make money. To make its case, The Times notes American doctors, • prescribe more drugs than European counterparts ( Did it ever occur to T he Times maybe, just maybe, European doctors “under-prescribe” and maybe their patients have less positive results? ) • conssciously endanger patients for profit when they know anemia drugs are unsafe (Has it occurred to The Times American physicians prescribing these drugs believe higher hemoglobin levels are “good” for improving health and alleviated distressing symptoms attributable to anemia.) • Continued to prescribe drugs even after studies indicated hemoglobin levels above 12 might endanger patients ( Did it ever occur to The Times the studies indicating “possible” risk studies were far from conclusive and only appeared in March?) Nor does The Times point out doctors themselves often criticize thenselves. For instance, on a May 11 blog, “The Doctors Weighs in on Cancer,” Dr. Dov Michaeli, an academic physician and biochemist who does cancer research takes the American Society of Clinical Oncologists (ASCO) to task for responding to the Times defensively (see epilogue to this blog for a reprint of ASCO letter to The Times). Of the ASCO letter to the times (reprinted in epilogue), Dr. Michaeli acidly comments “ASCO makes that same argument that professional people make when colleagues are caught with their hands in the cookie jar: most of us are conscientious, hardworking people. Granted, but it turns a blind eye to the corrosive influence of pharmaceutical companies on the use of drugs. This is denial of how our health system ‘works’ on a daily basis.” Michaeli concludes: “As the wheels are coming off our broken health system, more revelations of waste, abuse, greed and outright criminality are bound to surface. What are we going to do about it?” Good question. I suggest we start with a more balanced view of the system. • First, I reject the notion the system is “broken” – and constant reference by academic critics of greed by practitioners as a cause for this brokenness ( Michaeli, an academic researcher, shows some of this bias when he says, “ ASCO is led by academic clinicians and researchers, whose motivation and dedication is admirable. But many of the rank and file, community practitioners, are not beyond temptation.” I doubt medical academicians, who compete for pharmaceutical company grants and who run clinical trials, are beyond temptation. I’m unaware academic physicians wear halos and only practicing doctors are vulnerable to “temptation.” • Second, I believe critics ought to acknowledge health care is an innovate force in our economy, will soon represent 20 percent of the nation’s GNP, and is the nation’s largest employer. Professional managers, whose job is to maximize resources and revenues, run most health care enterprises - hospitals, medical practices, drug and device manufacturers. If overzealous pursuit of revenues and resources leads to excess, managers should be condemned, even fined and jailed, but it shouldn’t be assumed or taken for granted pharmaceutical and medical device companies and doctors are always seeking mutually beneficial arrangements are ipso facto evil doers. What the media in general, and The New York Times in particular, needs is a more balanced view. An occasional dollop of good news, such as more than 50 percent of cancer victims are now surviving, more than 10 million cancer victims are living with their disease, and genetically engineered cancer drugs are contributing significantly to cancer cures, would help achieve that balance. I’m pleased to report the May 12 issue of The Times contains a “good news” piece on Becton, Dickinson & Company. It’s buried on the third page of the business section. It’s titled “Medical Gear That Rarely Makes News.” It consists of an interview with Edward J. Ludwig, CEO of Becton and Dickenson, with revenues of $5.7 billion last year, on sales of syringes, diagnostic kits, lab equipment, and related gear. The unifying theme behind the company’s success is its emphasis on safety in its products to protect doctors, nurses, and patients with shields, sliding clasps, and needle retracting into the device. Its ambition is to make a significant dent in the 2 million infections each year from antibiotic resistant staphococci killing 90,000 Americans each year and costing $6 billion yearly to treat. Toward that end, B &D has acquired a diagnostic system allowing them to quickly identify the offending bacteria. Use of this system to screen every patient. entering Evanston Northwestern Hospital reduced infections by 60 percent. Ludwig contend s private innovation will help the “broken” health system to heal itself by attacking safety problems, and improving care. What the media needs is a new more flexible mindset allowing them to become more innovative in reporting the “good news” of our resourceful and responsive health system. Epilogue : In the interest of being “fair and balanced” (a term the mainstream media now considers anathema since Fox News adopted it as their slogan), I reprint six letters from the May 13, Sunday, New York Times. The Times deserves credit for publishing letters representing both points of view. Best Drug, or Best Money Maker? (6 Letters) 1) To the Editor: So two drug companies are paying hundreds of millions of dollars to doctors who prescribe anemia medicines that lack effectiveness and put a patient’s health at risk. This is not a surprise because it reflects our broken health system, a system driven by greed. Although drug companies say their intentions are not to promote the use of more medicine for profit, there will always be the risk that some doctors will prescribe higher doses to gain that extra dollar. As patients, we should work to eliminate the incentives to doctors and to raise patient awareness about them. We deserve the right to know the benefits of a medicine, both for us and for the doctors. Luis Rodriguez Daly City, Calif., May 9, 2007 2) To the Editor: Medical care should be guided only by what is best for patients. But throughout the medical system, rebates and volume discounts are common and can create the perception of improper incentives. Our organization has long advocated evidence-based guidelines, including those we produced in 2002 with the American Society of Hematology on erythropoietin use for chemotherapy-related anemia. With the appropriate use of erythropoietin, many thousands of patients have avoided potentially dangerous blood transfusions. Oncologists care deeply about their patients, and the overwhelming majority treat them based on the best available evidence. In the case of erythropoietin, recent studies prompted the Food and Drug Administration to issue a “black box” warning in March about the potential dangers of using erythropoietin to boost hemoglobin to levels higher than guidelines recommend. Early evidence suggests that doctors factored this new data into their prescribing decisions and have reduced erythropoietin use. As a whole, the medical community needs to better determine the impact financial incentives may have on prescribing patterns and patient care, to ensure that patient needs continue to be at the forefront of medical decisions. Allen S. Lichter, M.D. Exec. V.P., American Society of Clinical Oncology Alexandria, Va., May 10, 2007 3) To the Editor: Many doctors appear dissatisfied with fees ethically garnered from clinical evaluation and management. They can and will prescribe for personal profit, and will readily reshape and expand diseases to suit the available reimbursement. Without disclosure, patients are typically the last to know there might be a problem. The investigation of anemia drugs no doubt could expose the self-serving logic, unethical inducements and poor administrative surveillance that permit exploitation of the public’s soft financial underbelly. Unfortunately, there are plenty of other specialties of medicine where such professional betrayals occur. And adequate regulation is not likely to occur in the financial free-for-all of private medicine. James H. Lampman, M.D. Bismarck, N.D., May 9, 2007 4) To the Editor: The discovery and development of growth factors that stimulate the bone marrow to produce red cells was a milestone in modern medicine. In the appropriate setting, these growth factors can improve blood counts and quality of life and spare patients time-consuming, expensive, short-lasting and risky transfusions. In our practice the increasing use of these medicines is driven by the fact that they work so well. As with any new therapy, these medicines need to be used within established and developing guidelines to avoid serious side effects. Since there are two competing and equally effective drugs, the drug makers are offering incentives for preferential use — the natural outcome of a free-market economy. Deciding how regulators might control drug makers is an important undertaking, but it should not detract from the tremendous benefits of these drugs when used in the right situation. Birjis Akhund, M.D. Chief of Medical Oncology Huntington Hospital Huntington, N.Y., May 9, 2007 5) To the Editor: America has the best medical care in the world. It is the most advanced and expensive. The first two qualifications are debatable, but the third is difficult to refute. The great expense is complicated by the high cost of drugs and procedures of dubious benefit. The likelihood of being prescribed drugs of dubious benefit is obviously increased by kickbacks to doctors. The kickbacks may be legal, but should they really be allowed? The cost of medicine is increased by this practice, and the quality is sure to suffer. Alex Floyd Lexington, Ky., May 9, 2007 6) To the Editor: “Doctors Reaping Millions for Use of Anemia Drugs” (front page, May 9) was disturbing. I found it equally disturbing that the continuation of the article was in Business Day. In the past two decades, I have observed that news of important medical advances increasingly appears in, or is continued in, the business section. This practice advances the thinking that health care is primarily a business in which providers reap riches, rather than a humane social endeavor in which providers earn their living. Ira D. Feirstein, M.D. New York, May 9, 2007

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Researchers at the University of Texas Southwestern Medical Center, Dallas, deleted the PTEN gene in parts of the brain of mice and found they exhibited autistic-like traits. The researchers deleted the PTEN gene from parts of the hippocampus and the front of the brain. The hippocampus is an important part of the brain for memory, as well as for some other functions. They found the mice exhibited deficits in social interaction. They were also much more sensitive to some stimuli which most mice would not normally be bothered with. You can read about this study in the journal Neuron (May 4). PTEN mutations in humans with autism spectrum disorders (ASD) have also been reported, although a causal link between PTEN and ASD remains unclear. The author of the study, Dr. Luis F. Parada, said "The exciting thing about these mice is it helps us to zero in on at least one anatomic location of abnormality, because we targeted the gene to very circumscribed regions of the brain. In diseases where virtually nothing is known, any inroad that gets into at least the right cell or the right biochemical pathway is very important." Physical evidence for the reason for sensory overload, a problem experience by people with autism, was visible in the mice with the PTEN gene deleted. Scientists noticed the nerve cells in their brains were thicker than they should be, they also had more connections to other nerves than would be the case in mice without the deletion of that gene. The researchers were excited that this discovery, thicker nerve cells and more connections between nerves, may be the first discovery of the anatomical regions where things go wrong in autistic patients. The scientists plan to try out drugs with these mice. The aim will be to find out whether their condition can be reversed. The researchers observed the following behavioural differences between normal mice and the mice with the PTEN gene deleted: -- The PTEN deleted mice showed no interest in strange mice. Normal mice did. -- On being presented with both another mouse and an inanimate object, the normal mice would be more interested in the other mouse. The PTEN deleted mice showed equal interest in both. -- The normal mice, on being presented with new nesting material, would team up and start making a nest. The PTEN deleted mice would ignore it. -- Female PTEN deleted mice would not care for their young well, many of their young died. -- When placed in an open area the PTEN deleted mice became very stressed, unlike the normal mice. -- The PTEN deleted mice became very stressed when gently picked up by humans, the normal mice rarely became stressed. -- The PTEN deleted mice were much more stressed by sudden noises than the normal mice. 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During the 2002 Deutsche Schulbasaar (um, that’s the German School Beerfest folks), Big Dave and I matched each other pint for pint. We drained those pint mugs ten times each and had the best time ever! Although one thing that annoyed Big Dave was the frequency with which I needed to go pee. He couldn’t believe it! Its like I needed a slash every five minutes, like I was a racehorse or something. Unfortunately there was nothing I could do about it, because as you know, once you’ve broken the seal, you just have to go with the flow (excuse the pun). I thought that I was doomed for life, that this would be my cross to bear (along with my sex addiction). But a few months later at the following year’s Wits vs RAU annual cricket match, after bitterly complaining about my unusual, persistent and irritating urinary condition, a very wise man told me his theory of “When to break the seal”. (By the way, this was the same wise man who once got a testicle stuck in the small gap between a door and its frame. Use it – don’t use it.) Anyways it went something like this: “Next time you’re drinking like a fucken m*thafucker and you need to take your dog for a walk, put it off, dickhead! Hold it so long that it starts to get painful. In fact, if its not excruciatingly painful when you walk, you’re breaking the seal too early, man! This stretches your bladder enough so that you won’t need a piss as often as you usually do, leaving you free to spend more time spading bitches and less time holding your cock in the bog.” And it was so. My first opportunity to try out this new theory was that very event. I held it in until I was bursting and finally experienced the most satisfying whizz ever. I finally understood why most men let out gratifying groans whilst standing at the golden trough. My loo-visiting frequency noticeably improved that day, but it still wasn’t great. However, after many years of practicing this technique, I have finally gotten to holding it in for a respectable (and even admirable) length of time. Subsequently I heard medically-related rumours saying that holding your wee-wee can make a man impotent, and I’ve relaxed applying this technique since. In fact, I’ve heard that if you hold it TOO long, and miss your window of opportunity, you’ll spring a leak, which is only temporary, but will last long enough to ruin your evening. Nothing can be done to reverse the effects of NOT “Breaking the seal” in time. Apparently blaming a splash from the basin taps wont work all night either. So use this technique with caution. But next time you’re smashing it in your face and don’t want to have to leave the action every few minutes to go and spend a penny, remember the wise single-balled man and his galling theory. It worked for me. cheap oem software buy software

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The up side of having been under the weather for so long is that I have gotten quite a bit of knitting done. Exhibit A : The Wonderful Wallaby This is the first of two, intended to be an early birthday present for a friend's twins. I have some red 1824 wool set aside for the second sweater, and will cast on as soon as I can lift my head from my pillow for more than 10 minutes at a time. Exhibit B : Austermann Step socks They're still not exactly what I was thinking of when I cast on, but oh, boy, do they feel good on my feet. Exhibit C : Tiger socks I am knitting these for a friend, all the while crossing my fingers that her sense of whimsy is as well developed as I think it is. Now, the down side of having spent all this time sitting in my chair/lying on the sofa and feeling sorry for myself (aside from the amount of work that is building as I tell anyone who will listen that housework just isn't possible right now ) is that I have been watching way too much daytime television. And getting waaaay too involved in what I'm seeing. There is no reason on God's green earth that I should actually have an opinion about where Anna Nicole Smith should be buried, let alone who her daughter's father may be. But what really has me steamed is the Discovery Health Channel. During the day their programming is geared towards the people they think are watching ... stay-at-home moms. The Baby Human is followed by Birth Day, which is in turn followed by House of Babies ... because apparently having children renders a woman incapable of thinking about anything except babies. You've had a little one? No more news for you! No, little lady, what you need is a steady diet of Yummy Mummy, along with a dollop of Runway Moms, just in case you were feeling o.k. about your own post-partum body. But what really, REALLY has me annoyed isn't the baby shows. It's Adoption Stories. Don't misunderstand ... I'm pleased that the Powers That Be at the Discovery Channel are capable of acknowledging that not all families start with a mommy-and-a-daddy-who-love-each-other-very-much. But I wish they'd stop writing scripts that have the narrator saying things like, "John and Betty decided to adopt after having three children of their own ," or "Ellen and Bill were saddened when they learned that they'd never have children of their own , so they turned their attention to adoption." (emphasis mine) Note to the script writers : A child who has been adopted is as much their parents' child as any biological children they may have. To say otherwise is to imply that there is something tenuous about their relationship ... that it is somehow weaker than one the parents would have with a biological child. I was adopted when I was six weeks old. My standard response when people ask me if I know my "real" mother is, "Of course I do ... she's the woman who raised me." And I double-dog-dare anyone to suggest to my mother that she's just someone who took in a poor illegitimate baby that nobody wanted, or that she is in any way less my mother than I am the mother of the children to whom I have given birth. She may be 75 years old, but she'll take you out. I realize that not all adoptees are lucky enough to have had as good a relationship with their parents as I have had with mine. But I would point out that having a biological connection to one's children doesn't guarantee that you understand them better, or that it is in any way certain that your relationship will be nothing but loving, nurturing, and mutually supportive. The news is full of stories of biological parents who have done unspeakable things to their little ones. It is hard to realize that there are people out there who diminish your love for your family simply because of the way that family was formed. And you'd think that a television show that purports to show the happy, shiny face of adoption would know better. Labels: Green Sock Knitalong, Wallaby buy software cheap oem software

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Along Wednesday, the first over-the-counter load bomb drug was accepted closed the FDA to treat obesity. Orlistat which is to be partnered with a low calorie diet, is expected bygone manufacturer GlaxoSmithKline to bid shelves up that summer to boot should hire dieters round 12 to 25 dollars a turn. The 60 mg real estate is to be taken 3 to 4 times a instance before consuming a meal this covers stupendous. This is the definite completed the counter hindrance future home medication to be established closed the FDA. Conceptioning to HealthDay News, “Eating a meal with again often stupendous throughout stock the drug can smoke mid bowel changes congenerous over loose stools, pacting to the FDA. These sector devises primarily roll out amid the first weeks of trick, they aren't harmful, plus can be managed closed onlookers the set diet of nearby 15 grams of immense per meal, GlaxoSmithKline said. It's and mandatory this prospects estimate a multivitamin once a space, at bedtime, seeing the drug can interfere with the absorption of some vitamins, GlaxoSmithKline said.” Although Orlistat is the unique FDA vanilla shot dog medication, essay has not wriggle subtracting criticism. The advocacy gathering General public People spoke out apophthegm, “At a extent throughout colon cancer is a leading narration of future home along with disease intervening the United States, the Food along with Drug Order's aim to praise, thanks to over-the-counter further, a diet drug that clearly fashions precancerous lesions of the colon is the degree of recklessness moreover bursts a profound call for of territory owing to the family's health.” Contents is no trial an argument that is gripping America during reserve until runnerup countries everywhere the terrene. Today, 30% of Americans 20 or older are considered obese age 36% are overweight. buy software cheap oem software

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Post Cylce Recovery Anciliaries Ok. I’ll admit it. I didn’t know much about anti-estrogens and their ilk before I started researching this article. And I’ll admit another thing: I didn’t care. I knew that 10mgs of Nolvadex per day was all I ever needed to not get gyno, though 50 mgs/day of Clomid seemed to work the same for me. Cytadren (remember that stuff?) worked for me also, at 250mgs/day, but it seemed to make me more prone to joint problems. HCG worked best for me when I shot 500i.u. every other day post cycle for about 3 weeks. Arimidex was too expensive. AND THAT’S ALL I NEEDED TO KNOW! Now nobody uses Cytadren anymore. We have affordable Arimidex (Anastrozole) in liquid form. We have Femera. And I had work to do to catch up. In the long run, I wasn’t that interested in what all this other stuff did because I already knew what worked for me. Well, keep reading and you’ll find out why I was wrong, what my new plan is for during a cycle and post-cycle recovery, and some other interesting stuff about not getting any side effects from roids.Here we go! So, first things first. Some steroids convert to estrogen. This is through the aromatase enzyme, and is called (duh) aromatization. When this happens you can get side effects associated with having too much estrogen, including bloating, gynocomastia, acne, and so on. Some steroids on the other hand, have progesteronic activity (deca, for example). The symptoms (acne, etc...) are the more or less the same for progesteronic and estrogenic effects. Note that I didn’t say that these other steroids convert to progesterone, but rather that they have progesteronic effects. That’s because the steroid is able to act on the progesterone receptor without conversion to another substance. Hence, on my current 600mgs per week of Deca and my 750mgs per week of Test, anti-estrogens will only help with the aromatization of the test and not the progesteronic activity of the Deca I’m taking. Know what else? Here are a bunch of other compounds that don't aromatize (thats good news) activity and hence don't needm any amount of anti-estrogens: Methenolone, Stanozolol, Dromostanolone, Oxandrolone, Mesterolone, Stenbolone, and Trenbolone. Taking a big dose of any of these? Anti –estrogens won’t help much if at all, per se, but keeping estrogen levels low is still a good idea. Remember, estrogen still has a role to play, even sides, in ways we don't fully understand yet. Not only that but if you take progesteronic gear and use nolvadex, you may be at an increased risk for progesteronic sides, as nolvadex may increase progesterone receptors (Gynecol Oncol. 1999 Mar;72(3):331-6.). What can you do? Well, the easy answer is to take bromocriptine (parlodel) at 2.5 to 5mg every day. Bromocriptine is one of those drugs that the life-extention crowd were very big on a few years ago. It is an anti-parkinsons medication which causes higher levels of the neurotransmitter dopamine, with side effects being an increased sex drive, possible curbing of appetite, possible stimulation of CNS, and fat loss. It’s also indicated for some forms of male hypogonadism (yeah, so it may increase test levels on its own!). However, what we’re interested in here is that it can be used to lower prolactin and progesterone. [Side note: A few tabs of Cabergoline per day will also lowe prolactin and improve sexual function. I just couldn't figure out where else this would fit into this post.] Back to Bromo...it sounds almost perfect, right? Well, unfortunately, bromocriptine is also used to treat acromegaly (too much GH produced by the pituitary), and ergo may lower GH levels in your body! Fortunately, the dosage needed to halt overproduction of GH in your body is 10-20mgs/day, so we’re safe with our amount necessary to stop from growing breasts from too much deca…and yes, all the cool fat burning, sex drive, and nootropic “side effects” happen at 2.5-5mgs/ day doses. As a side note, taking 25mcg of T3 or maybe 50-100mcgs of T4 may be effective for eliminating some if not all of the chance of getting gyno from tren. And yeah, I have the research to back that statement up, but it involves another page of reading about TRH, TSH, the negative feedback loop involved with low levels of T4 stimulating TRH, blah blah blah. Trust me, you don’t care about the reasons why this works, just that it does. If you’re doing tren, take some T3 and you’ll get increased fat-burning, no gyno, and more maybe even anabolism. So if I were cutting up, tren, T3 (25mcgs), and bromo would all be part of my stack , and I’d expect to get really cut really fast (of course, there’s other cool drugs I’d add into that mix…clen, test, etc…but this is about anciliaries, not a cutting cycle). Another idea to reduce progesterone is to take RU486 (yeah, the pregnancy drug). This drug has anti-progesteronic effects, and in women 600mgs totally plocks progesterone. Don’t even think about taking this dose, though…I’d reccomend taking around 50 mgs a day and working your way up. Remember, cortisol is also decreased with RU486, so sore joints may be a problem. Considering this, bromo’s cool secondary effects, and price, I’d consider bromocriptine a better choice. So what steroids do aromatize? Here’s the some of the worst offenders: Testosterone, Methandrostenolone, Boldenone , Fluoxymesterone, (only in high enough doses)…you get the idea.And Deca...yeah it even aromatizes, besides being a progestin, though not much. Everyone still with me? Okay, so what are some drugs that inhibit aromatization? Cytadren (aminoglutethemide), at 250-500mgs per day will do the trick, as will Arimidex at .5-1mg per day (more about Arimidex later, and remember, this is all dependant on what doses of aromatizing drugs you’re taking). Cytadren also limits the conversion of test to DHT, which may help eliminate any hair loss during a cycle. [Finesteride (Propecia = 1mg tabs, Proscar = 5mg tabs) has similar effects with regards to halting some of DHT’s negative effects.]. Cytadren may also slightly inhibits test production, so that kinda turns me off to it. Especially when other drugs actually increase test production and will prevent side effects more effectively. Unfortunately, cytadren has a really short ½ life, and it ideally should be taken 2-3x a day. That plus its cortisol inhibiting effects (and the sore joints you get from that) don’t make it really ideal for me. On the bright side, Cytadren may improve blood lipid profiles. What else can we do to avoid side effects? Well, we can block the receptors that the estrogen attaches itself to, thus causing the side effects. Clomid (Clomiphine Citrate) and Nolvadex (Tamoxifen) will do this. As these drugs are selective in their activity, they are estrogenic to certain receptors (blood lipid profiles are favorably enhanced by the estrogenic action of these drugs), and antiestrogenic to others (they are anti-estrogenic in terms of their action on breast tissue, for example…and yes I know that Nolvadex is actually a weak estrogen that blocks out the competing stronger estrogens with regards to attaching to the receptors in breast tissue…I’m trying to keep things relatively simple, though). Generally Nolvadex is cheaper than Clomid, and thus more often used. Now dig this: According to William LLewellyn, studies conducted in the late 1970's at the University of Ghent in Belgium used Nolvadex for 10 days at a dosage of 20mg daily, which increased serum testosterone levels to 142% of baseline, on par with the effect of 150mg of Clomid daily for the same duration! Depending on what you read into this, I’d say that Nolvadex is a superior buy for post-cycle recovery. That being said, Nolvadex is good, but not quite perfect, as it lowers IGF-1 levels. Post-cycle, though, when I’m worried about returning test-levels to normal, I’m not too worried about IGF-1 levels. Though, I’ve found testicular atrophy during a cycle is attenuated to a greater degree by Clomid. So besides competing with estrogen at the receptor, these drugs both increase serum test levels, and both drugs may also alter blood lipid profiles. I couldn't find the studies W.L. mentioned, but still found that 20mgs of tamoxifen is equal to 150mgs of clomid for purposes of testosterone elevation, FSH and LH, but tamixifen did not decrease the LH response to LHRH (Fertil Steril. 1978 Mar;29(3):320-7.). Thus, I'd still reccomend Nolv over clomid. Actually, I think nolvadex is far superior to clomid for most purposes. As Nolvadex isn’t actually an anti-aromatase, but rather a competitor for the receptor site, and seeing as it increases test levels so much, I’d say that it’s actually a better post-cycle drug than Clomid. At least I know that it’s what I’ll be using post-cycle, even despite its effects on IGF-1. Cyclofenil (remember that drug?) will do just about everything with regards to halting estrogen’s binding to receptors that the other two drugs I just discussed will do, but helps LH production to a greater degree. Lowering your LH (in addition to having an adverse effect on the general recovery of your entire hormonal system) will also contribute to estrogenic-type effects. Raising LH = Good. Lowering LH = Bad. Most people take a tab or 2 per day of this stuff, in any case. There’s better stuff on the market, though. Now onto Femara (AKA Letrozol), which is more effective than Arimidex in it's ability to pass thru the cell membrane of lipid (fat) cells and inhibit the activity of aromatase -- Arimidex is just over 80% effective at inhibiting aromatase, Femara is around 95-97%. Other than that, both of these drugs stop the process of aromatization, rather than just blocking the receptors as Clomid and Nolvadex do. An effective dose of Letrozole is 1-2.5 mg/day, but be forewarned, it can kill your sex drive, and could decrease IGF levels. On the other hand, I’ve seen studies where it increases IGF levels. Also worth noting is that there’s a rebound effect when you come off letrozol. As of this time, the jury is still out this drug, in my mind. (1. J Clin Endocrinol Metab 2000 Jul;85(7):2370-7 2. J Steroid Biochem Mol Biol 1997 Nov-Dec;63(4-6):261-7) How about Aromasin? Well, its totally different than everything else we’ve looked at so far. Aromasin (exemestane) it is a aromatase inactivator...It actually makes estrogen receptors useless. Instead of just inhibiting production (as an anti-aromatase would do) it cuts off production totally. Aromasin can effectively prevent about 90-95% of estrogen conversion. And though it won’t kill your sex drive, just like Nolvadex, it decreases IGF-1 levels by about 23-24%. Worth noting is that Aromasin may be less harsh on blood lipids than most of the other compounds mentioned here (with the exception of Nolvadex which may actually improve HDL & LDL). Lets talk about Arimidex (Anastrozole), now. From the research I’ve done, this seems to be the best thing around and I’ll tell you why. First off, ‘dex is an aromatase inhibitor (remember what that is?). 1mg per day of this stuff (J Clin Endocrinol Metab 2000 Jul;85(7):2370-7, “Estrogen Suppression in Males”) was shown to decrease estrogen by 50% and increase testosterone levels by 58%. LH and FSH also went up slightly. The test increase didn’t happen at a dose of .5 per day, but estrogen suppression was the same. Anastrozole also raises IGF1 and shows a trend towards increasing IGF2 (J Steroid Biochem Mol Biol. 2002 Apr;80(4-5):411-8) BTW, literature provided by the original maker of Arimadex states that stable blood plasma concentrations of the compound are achieved after 7 consecutive 1mg daily doses. All of that plus the usual blood lipid changes we’ve seen with most of the anciliaries we’ve looked at! Anyway, that’s a pretty hefty decrease in estrogen, even at .5mg/day. For my money, if I wanna stop aromatization during a cycle, I’m gonna use Arimadex at .5mgs per day. Its the perfect during-cycle ancillary. What about HCG (Human Chorionic Gonadotropin)? For starters, it increases (stimulates) endogenous (natural) testosterone production. It’s ideal for post-cycle. I’ve found personally that 500IU every other day or even every day, post-cycle works best for me. Incidentally, this is the PDR (and Dan Duchaine's) reccomendation. In one study I looked at, 6000IU of HCG elevated test levels for 6 days. That’s why a lot of people recommend taking it every 3-5 days. I’d have more stable blood levels, though if I shot it more frequently …remember, it’s a water-based injectable, after all. In that same study I read, 1500IU of HCG shot test levels up between 250 and 300%. Again, though, I’d be more comfortable with the more stable and slow increase. Also, keep in mind that HCG suppresses FSH and LH production and has been anecdotally linked to gyno. Thus, it (in combination with Nolvadex) is ideal for post-cycle recovery…when gyno is not as much of an issue (due to the nolvadex and the cessation of other compounds), but restoring natural test levels is. SO…lets review: During a cycle (because I ALWAYS use test in my cycles), I think it’s a good idea to use Arimadex at .5-1mg per day, 2 take care of aromatization, thus preventing side effects related to estrogen. If I’m using gear that has progesteronic side effects , I'm gonna avoid nlovadex, and I’m gonna have to throw in some Bromocriptine at 2.5-5mgs every day, especially when I’m using lots of Tren (and perhaps trying to get cut) I’d want the added "side effects" we already discussed from the Bromo, and I'd thrown in that T3 as well. When I’m all done with the cycle, Nolvadex (at 10-20mgs/day for a month) post cycle, plus 500-1000 IU of HCG every other day (for 2-3 weeks) will help restore test levels to normal. Clomid at 50mgs per day will …umm….keep or return your nuts to a normal size, and will have anti-estrogenic and pro-gonadotropic effects. I like it during a cycle to keep my nuts big. Sorry, there’s no really polite way to say that stuff about keeping your nuts normal.... But in any case, I’d run the Clomid for about 2 weeks of the start of PCT if this was a concern, or during the cycle...possibly for the last 2 weeks, if you want. I use it quite alot, myself, during a cycle (100mgs/day). Although I've been shying away from it recently due to the relative inexpensiveness of other, better compounds...and the fact that clomid messes with my vision. So there it is. I hope this answers some questions for everyone.

Tags: day, mg, effect, cycle, estrogen

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